Wednesday, 16 June 2021

08:55 – 09:00

Introduction to Keynote Speaker

09:00 – 09:40

Keynote: Global Harmonization – Togetherness for the Effective Implementation of the 3Rs of Animal Use within the Toxicity Assessments of Chemicals and Pharmaceuticals

Fiona Sewell, NC3Rs, UK

Day 3 Subtheme: Advances in Toxicity Testing for Product Safety

09:40 – 09:50

Symposium 6: Advance Topics in Toxicologic Pathology

Chair: Maria Lucia Zaidan Dagli, Uni. of Sao Paulo, Brazil

Symposium 7: Recent Advances in Liver Disease: from Non-Alcoholic Fatty Liver Disease (NAFLD) to Fibrosis

Chair: José Manautou, Uni. of Connecticut, USA

Symposium 8: 3Rs Alternatives for Regulatory Testing

Chair: Masao Fukumura, PETRONAS, Malaysia

09:50 – 10:20

The Essential Use of Rodent Models for Toxicological Endpoints in Cancer Research

Maria Lucia Zaidan Dagli, Uni. of Sao Paulo, Brazil

Environmental Chemicals as Risk Modifiers for NAFLD

Juliane Beier, Uni. of Pittsburgh, USA

Medical Devices and Non-Animal Methods for Toxicological Risk Assessment

Christian Pellevoisin, Episkin, France

10:20 – 10:50

Bridging the In Vitro and In Vivo Histopathological Evaluation for the Pharmaco Safety Assessment

John R Foster, ToxPath Sciences Ltd., UK

Impact of Multidrug Resistance Protein 4 (Mrp4) Function on Hepatic Lipid Accumulation

José Manautou, Uni. of Connecticut, USA

Integration of the 3Rs Alternatives in the Safety Testing for Nanotechnologies

Sasitorn Aueviriyavit, NANOTEC, Thailand

10:50 – 11:10


11:10 – 11:40

Comparative Pathology of the Toxicity of Drugs and Environmental Chemicals for Human Risk Assessment: Are Rodents Relevant?

Jerrold M. Ward, Global VetPathology, USA

Genetic Susceptibility to Non-Alcoholic Fatty Liver Disease: Asian Genome

Guruprasad Aithal, Queen’s Medical Centre, Nottingham, UK

Applying Zebrafish Embryo Acute Toxicity Test in China: Status and Prospect

Zhenlie Huang, Southern Medical Uni, China

11:40 – 12:10

A Toxicologist’s View of Modern Safety Assessment

Wolfgang Dekant, Uni. of Würzburg, Germany

Inorganic Nanoparticles: Impact on Endothelial Biology Liver Fibrosis

Ho Han Kiat, National Uni. of Singapore, Singapore

Current Views on the 3Rs Adaptation for the Skin Sensitization Testing

Takao Ashikaga, NIEHS, Japan

12:10 – 12:30

Question and Answer Session

12:30 – 13:30


13:30 – 13:40

Forum: Women in Toxicology

Chair: Razinah Sharif, Uni. Kebangsaan Malaysia

Oral Session 6: Nanotoxicology

Chair: Siew Ee Ling, Uni. Kebangsaan Malaysia, Malaysia

Oral Session 7: Occupational, Clinical or Regulatory Toxicology

Chair: Ahmad Faizal Abdull Razis, Uni. Putra Malaysia

13:40 – 14:10

A Portfolio Career in Industry and Academia

Ruth Roberts, ApconiX

Silver Nanoparticles Induced Apoptosis in Hippocampal Neurons through Mitochondrial Dynamics via Elevating Intracellular ROS and Ca2+ Level (OS8-O01)

Chang Xiaoru, Southeast Uni., China

Educational Resources for Training in Non-Animal Regulatory Testing Methods in Developing Countries (OS8-O05)

Esther Haugabrooks, PCRM, USA

14:10 – 14:40

Exploring In Silico Toxicology from a Malaysian's Perspective: The Journey from Europe to Back Home.

Rozaini Abdullah, Uni. Putra Malaysia

Protein Corona Mitigated the Toxicity of Cadmium Telluride Quantum Dots to Macrophages by Targeting Mitochondria (OS8-O02)

Na Liu, Southeast Uni., China

Challenges of GHS Implementation Worldwide (OS1-O02)

Goh Choo Ta, Uni. Kebangsaan Malaysia, Malaysia

14:40 – 15:00


15:00 – 15:30

Traditional Herbal Poisoning in Vietnam

Uyen Vy Doan, Cho Ray Hospital, Vietnam / National Yang-Ming Uni., Taiwan

Toxicity of Curcumin Nanoparticles in Alveolar Macrophage: Effects of Surface Charges (OS8-O03)

Lee Wing Hin, Uni. Kuala Lumpur, Malaysia

Microplastic Exposure, Possible Health Impact and Policy Measures (OS1-O03)

Ahmad Faizal Abdull Razis, Uni. Putra Malaysia, Malaysia

15:30 – 16:00

Misuse of Prescription Drugs in Singapore: An Insight from Public Health Specialist

Chan Wui Ling, Singapore SOT

Macrophage Polarization and Inflammation Induced by Silver Nanoparticles via Autophagy in BV2 Cells (OS8-O04)

Mengting Shang, Southeast Uni., China

Safety Pharmacology Test of Plant-Based COVID-19 Vaccine in Non-Human Primates (OS1-O01)

Suchinda Malaivijitnond, Chulalongkorn Uni., Thailand

16:00 – 16:20

Question and Answer Session

16:20 – 16:30

Closing Speech & Announcement of the venue of CTDC12 (MySOT President)

16:30 – 16:40

CTDC12 Host Presentation